Targeting telomerase for cancer therapeutics
One of the hallmarks of advanced malignancies is
continuous cell growth and this almost universally correlates with the reactivation
of telomerase. Although there is still much we do not understand about the
regulation of telomerase, it remains a very attractive and novel target for
cancer therapeutics. Several clinical trials have been initiated, and in this
review we highlight some of the most promising approaches and conclude by
speculating on the role of telomerase in cancer stem cells.